Facilitation by 3,4-diaminopyridine of regenerative acetylcholine release from mouse motor nerve
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چکیده
منابع مشابه
Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals.
Effectiveness against chloroquine-resistant Plasmodia makes mefloquine a widely used antimalarial drug. However, mefloquine's neurologic effects offset this therapeutic advantage. Cellular actions which might contribute to the neurologic effects of mefloquine are not understood. Structural similarity to tacrine suggested that mefloquine might alter cholinergic synaptic transmission. Therefore, ...
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In order to elucidate the physiological role of endogenous adenosine in regulating the release of acetylcholine, the effects of 8-phenyltheophylline, an antagonist of adenosine receptors and dipyridamole, an uptake inhibitor of adenosine, on the contractile response and quantal release of acetylcholine during single and repetitive stimulations of isolated mouse phrenic nerve-diaphragm preparati...
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Neurotransmitters can modulate the release of other neurotransmitters from presynaptic nerve terminals, as has been described for "presynaptic inhibition" in the spinal cord (Eccles, 1964). Catecholamine and 5-hydroxytryptamine can alter the release of acetylcholine (ACh) from pre ganglionic nerve terminals in sympathetic ganglia (Christ and Nishi, 1971; Kuba et al. 1981; Hirai and Koketsu, 198...
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with urease. A third minor metabolite was present in urine collected after intraperitoneal administration but remains unidentified. The quantitative distribution of pterin-dcarboxylic acid and urea in the 0-24 h urine samples is shown in Table 1. Fukushima & Nixon (1980) reported the degradation of [2-14C]pterin-6-carboxylic acid to 14C02 by the gut microorganisms of the rat. It is possible tha...
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1. The effects of wortmannin, an inhibitor of phosphatidylinositol (PI) kinases and myosin light chain kinase, on the quantal release of neurotransmitter from mouse phrenic nerve were investigated. 2. Wortmannin (10 - 100 microM) initially enhanced, thereafter progressively depressed spontaneous quantal discharge (miniature endplate potential, mepp). The mean amplitude and the amplitude distrib...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb14159.x